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Cost-effective and customizable 4-AMINO-2-METHYLPYRIMIDINE-5-CARBONITRILE 698-29-3 supplier
- Molecular Formula: C6H6N4
- Molecular Weight: 134.14
- Appearance/Colour: Pale-Yellow Crystalline Solid
- Melting Point: 249 °C
- Boiling Point: 315.6 °C at 760 mmHg
- PKA: 3.00±0.10(Predicted)
- Flash Point: 144.7 °C
- PSA： 75.59000
- Density: 1.27 g/cm3
- LogP: 0.82008
4-AMINO-2-METHYLPYRIMIDINE-5-CARBONITRILE(Cas 698-29-3) Usage
InChI:InChI=1/C6H6N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,1H3,(H2,8,9,10)
698-29-3 Relevant articles
Studies on the Thorpe-Ziegler-reaction. A new synthesis of the pyridine part of thiamine
Edenhofer,Spiegelberg,Oberhaensli
, p. 1230 - 1240 (1975)
-
Studies on metabolism of thiamine in rats. I. Cleavage of thiamine molecule in vivo.
Meshi,Sato
, p. 1445 - 1450 (1968)
-
Micro-reaction system and method for continuously preparing 2-methyl-4-amino-5-cyanopyrimidine by using same
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Paragraph 0016; 0075-0104, (2021/05/29)
The invention belongs to the technical f...
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1
Chen, Fener,Huang, Huashan,Jiang, Meifen,Liu, Minjie
, p. 2331 - 2337 (2021/10/25)
Herein, we demonstrate an expeditiously ...
Fully continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine
-
Paragraph 0006; 0045-0046; 0048-0061, (2021/07/17)
The invention discloses a fully continuo...
Synthesis and fungicidal activity of novel 1,2,4-triazole derivatives containing a pyrimidine moiety
Wu, Wen-Neng,Jiang, Yang-Ming,Fei, Qiang-,Du, Hai-Tang
, p. 1171 - 1175 (2019/07/05)
A series of novel 1,2,4-triazole derivat...
698-29-3 Process route
-
-
16849-88-0
1-(dimethylamine)-2,2-dicyanoethylene
-
-
124-42-5
acetamidine hydrochloride
-
-
698-29-3
2-methyl-4-amino-5-cyanopyrimidine
| Conditions | Yield |
|---|---|
|
acetamidine hydrochloride;
With
sodium methylate;
In
methanol;
at 0 ℃;
for 0.333333h;
1-(dimethylamine)-2,2-dicyanoethylene;
In
methanol;
at 55 ℃;
for 0.5h;
under 750.075 - 3000.3 Torr;
Temperature;
Pressure;
Inert atmosphere;
|
93.6%
|
|
acetamidine hydrochloride;
With
sodium methylate;
In
methanol;
for 0.166667h;
Cooling with ice;
Large scale reaction;
1-(dimethylamine)-2,2-dicyanoethylene;
In
methanol;
at 20 ℃;
for 12.5h;
Cooling;
Large scale reaction;
|
90%
|
|
With
sodium methylate;
In
methanol;
at 55 ℃;
for 0.5h;
Temperature;
Concentration;
Time;
Flow reactor;
|
90%
|
|
With
sodium methylate;
In
methanol;
at 0 ℃;
for 0.333333h;
Product distribution / selectivity;
|
65%
|
|
With
sodium methylate;
In
methanol;
|
|
|
With
sodium acetate;
In
methanol;
at 20 ℃;
|
-
-
ethanimidamide hydrochloride
-
-
16849-88-0
1-(dimethylamine)-2,2-dicyanoethylene
-
-
698-29-3
2-methyl-4-amino-5-cyanopyrimidine
| Conditions | Yield |
|---|---|
|
ethanimidamide hydrochloride;
With
sodium methylate;
In
methanol;
for 0.166667h;
Cooling with ice;
1-(dimethylamine)-2,2-dicyanoethylene;
In
methanol;
at 20 ℃;
for 12.5h;
|
97%
|
|
With
sodium methylate;
In
methanol;
at 25 - 50 ℃;
for 0.666667h;
Solvent;
|
698-29-3 Upstream products
-
27058-54-4
2-methyl-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile
-
38875-74-0
4-chloro-2-methylpyrimidine-5-carbonitrile
-
7389-14-2
2-methyl-4-amino-5-(carboxamidemethyl)pyrimidine
-
874495-29-1
4-ethoxy-2-methyl-pyrimidine-5-carbonitrile
698-29-3 Downstream products
-
1886-34-6
2-methyl-4-amino-5-formylaminomethylpyrimidine
-
108482-83-3
(4-amino-2-methyl-pyrimidin-5-ylmethyl)-(4-amino-2-methyl-pyrimidin-5-ylmethylen)-amine
-
95-02-3
5-(aminomethyl)-2-methylpyrimidin-4-amine
-
7389-14-2
2-methyl-4-amino-5-(carboxamidemethyl)pyrimidine
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